毛细血管内增生性肾炎伴肾病综合征和急性肾损伤

Endocapillary proliferative glomerulonephritis with nephrotic syndrome and acute kidney injury

急性肾小球肾炎简称急性肾炎,以儿童多见,成人少见,罕见伴有肾病综合征。国内外可见急性肾炎伴肾病综合征的零星报导。急性肾炎(或毛细血管内增生性肾炎)同时致肾病综合征和急性肾损伤更为罕见,国外仅见3篇报道,国内无明确报道。急性肾炎一般不使用激素治疗,而合并肾病综合征时使用激素与否尚有争议。现报告1例肾活检确诊为毛细血管内增生性肾炎的急性肾炎,并出现肾病综合征和急性肾损伤。该患者经过短期抗菌药物治疗和半年激素治疗后病情得到控制。

Acute glomerulonephritis can be referred to as acute nephritis. It is common in children, unusual in adults, seldom accompanied by nephrotic syndrome. Sporadic cases of acute nephritis associated with nephrotic syndrome have been reported both in China and abroad. It is rare that acute nephritis（or endocapillary proliferative glomerulonephritis） induced nephrotic syndrome with acute kidney injury, and only 3 cases reported in abroad, no clear reports in domestic. Steroids are not commonly used in acute glomerulonephritis, while the use of steroids in nephrotic syndrome remains controversial. We reported 1 case of renal biopsy confirmed endocapillary proliferative glomerulonephritis patients with acute nephritis, rarely manifested by nephrotic syndrome and acute kidney injury, and the disease was under control after short term antibiotics and half-year steroid treatment.