基于虚、毒、湿论治老年抗生素相关性腹泻

Treatment of Senile Antibiotic-associated Diarrhea Based on Theory of Deficiency,Toxicity and Dampness

结合老年人的体质特点,对老年抗生素相关性腹泻(AAD)的病因病机及治法进行理论探讨。认为脾肾阳虚是老年AAD的根本内因,为发病之本,而药毒、水湿则是重要病邪,为致病之标。基于"虚、毒、湿"致病说,采用健脾温阳、化湿解毒之法,可扶正祛邪、标本兼治,方用肉蔻四神丸、四君子汤,常用药物有肉桂、干姜、茯苓、白术等。

We discussed the etiology,pathogenesis and treatment of senile antibiotic-associated diarrhea（AAD）,in combination with the physical characteristics of the elderly.We believed the spleen and kidney yang deficiency was the basic etiology and pathogenic root of senile AAD while drug toxicity and dampness were the important pathogenic factors,which were the pathogenic branches.Based on the pathogenic theory of ＂deficiency,toxicity and dampness＂,by invigorating the spleen and warming yang,eliminating dampness and detoxicating,we could achieve the purpose of strengthening body resistance and eliminating evil,treating both the root and branch.The commonly used prescriptions include Roukou Sishen pill,Sijunzi decoction and the drugs include Cinnamomi cortex（Rougui）,Zingiberis rhizoma（Ganjian）,Poria（Fuling）,Atractylodis macrocephalae rhizoma（Baizhu）,etc.