围产期抑郁引发代际性抑郁障碍及机制

Maternal peripartum depression induced transgenerational depressive disorder and mechanisms

围产期抑郁(peripartum depression,PPD)可对母亲及子女产生不良影响,显著增加其子女罹患情感障碍的风险,并且这种影响可代际(transgenerational)持续。PPD引发代际性抑郁障碍的发病机制较为复杂,经典抗抑郁药物难以起到较好的治疗作用,因此,深入研究PPD引发情感障碍及代际性影响的分子机制具有重要意义。本文对下丘脑-垂体-肾上腺轴(hypothalamic–pituitary–adrenal axis,HPA)、催产素(oxytocin,OT)及其信号、突触可塑性以及表观遗传学机制在PPD引发代际性抑郁情感障碍的作用进行讨论,以期为下一步研究提供依据。

Peripartum depression（PPD） has adverse effects on both mothers and offpring, particularly by increasing the risk of emotional disorders in offspring significantly in a transgenerational manner. The pathogenesis of transgenerational depressive disorders from PPD is complex, and the current pharmacotherapeutic efficacy was limited. Therefore, it is of great importance to study the mechanisms underlying this disorder. We discuss the role of the hypothalamic-pituitary-adrenal axis（HPA）, oxytocin（OT）, synaptic plasticity and epigenetic mechanisms underlying transgenerational depressive disorders, to give insight for further in-depth research.