白色念珠菌与常见细菌相互作用的研究进展

Research progress on the interaction between Candida albicans and common bacteria

白色念珠菌是人体中常见的条件致病菌,其院内感染常常伴有细菌的混合感染.各种细菌与白色念珠菌间可能存在协同、竞争、偏益等关系,并以不同方式损伤宿主组织.混合感染将影响各病原微生物之间的生化关系及生物膜构成,进而改变病原微生物的耐药性及其对宿主免疫的抵抗力和毒力等,使得混合感染较单一感染更难治愈.白色念珠菌与细菌混合感染的高发生率及高死亡率是临床医生面对的严峻问题.了解白色念珠菌与细菌之间的相互作用机制对混合感染的临床诊治意义重大.对金黄色葡萄球菌、绿脓杆菌、链球菌、乳酸杆菌与白色念珠菌相互作用的研究进展作一综述.

Candida albicans is the most prevalent fungal species of the human microbiota.Many nosocomial Candida albicans infections are polymicrobial.The interaction between Candida albicans and other bacteria can be synergistic,antagonistic,and one side benefit,which cause damage of host in different way.Co-infections influence the biochemistry and polybiofilm among pathogenic microorganisms,and then change the drug resistance,response host immunity,and virulence.This makes co-infections more difficult to be cured than mono-infections.The coinfection of Candida albicans and other bacteria has a high incidence rate and mortality rate,which is a serious problem faced by clinicians.The mechanism of interaction between Candida albicans and other bacteria has an important significance in diagnosis and co-infection treatment.In this paper,the research progress of interaction between Candida albicans and Staphylococcus aureus,Pseudomonas aeruginosa,Streptococcus mutans,as well as Lactobacilli was reviewed.