玻璃酸钠关节腔注射治疗对膝骨关节炎患者膝关节功能、日常活动能力以及生活质量的影响

Effects of Intra-Articular Injection of Sodium Hyaluronate on Knee Joint Function, Daily Activity and Quality of Life in Patients with Knee Osteoarthritis

目的:探讨玻璃酸钠关节腔注射治疗对膝骨关节炎(OA)患者膝关节功能、日常活动能力以及生活质量的影响。方法:选取2015年4月-2016年4月在我院接受治疗的OA患者123例,按照患者对药物和针剂的意愿分为对照组60例和观察组63例。对照组采用非甾体类药物口服治疗,观察组给予玻璃酸钠注射液关节腔注射治疗,采用膝关节功能评定量表评价两组患者治疗前后膝关节功能情况,对比两组患者治疗前后日常活动能力改善情况,采用生活质量综合评定问卷(GQOL-74)评价两组患者治疗前后的生活质量,采用视觉模拟评分法(VAS)评价两组患者的疼痛程度。结果:治疗后观察组患者行走能力、上下楼能力、屈曲程度、肿胀程度、综合能力评分均高于对照组(P<0.05)。治疗后观察组端坐、上下楼梯、屈膝下蹲等日常活动能力显著优于对照组(P<0.05)。治疗后观察组患者社会功能、躯体功能、心理功能、物质生活评分显著高于对照组(P<0.05)。治疗后观察组VAS评分显著低于对照组(P<0.05)。结论:玻璃酸钠关节腔注射治疗OA能有效促进膝关节功能恢复,同时可以显著改善患者的日常活动能力以及生活质量,并减轻疼痛,值得临床推广应用。

Objective： To study the effects ofintra-articular injection of sodium hyaluronate on the knee joint function, daily activity and quality of life in patients with knee osteoarthritis （OA）. Methods： 123 patients with OA treated in our hospital from April 2015 to April 2016 were selected. All the patients were divided into observation group （63 cases） and control group （60 cases） according to the patients＇ willingness on drugs and injections. The control group was treated with non steroidal drugs orally, and the observation group was treated with sodium hyaluronate injection joint cavity injection. The knee joint function was evaluated by the knee joint function rat- ing scale before and after treatment in two groups, and the daily activity ability of the two groups before and after treatment was com- pared between the two groups. Quality of life comprehensive assessment questionnaire（GQOL-74） was used to evaluate the quality of life of the two groups before and after treatment. Visual analogue scale （VAS） was used to assess the degree of pain in the two groups. Results： After treatment, the scores of walking ability, the ability of upper and lower stairs,the degree of flexion, the degree of swelling and the comprehensive ability in the observation group were higher than those in the control group （P〈0.05）. After treatment, the ability of daily activities of sitting, walking up and down stairs and dip of knees in the observation group were significantly better than those in the control group （P〈0.05）. After treatment, the scores of social function, physical function, mental function and material life of the observation group were significantly higher than those of the control group（P〈0.05）. After treatment, the VAS score of the observation group was significantly lower than that of the control group （P〈0.05）. Conclusion： Intra-articular injection of sodium hyaluronate treatment on OA can effectively promote the recovery of knee function, improve the daily activity of patients, improve the quality of life, and reduce pain. It is worthy of clinical application and promotion.