参附注射液联合rhBNP对ICMHF的心功能及血浆BNP、hs-CRP水平影响

Impact of Shenfu injection combined with recombinant human brain natriuretic peptide on cardiac function,plasma BNP and hs-CRP in Ischemic cardiomyopathy heart failure

目的评价参附注射液联合重组人脑利钠肽(rh BNP)对缺血性心肌病心力衰竭(ICMHF)的治疗效果。方法将78例ICMHF患者单盲随机分为两组,各39例。对照组给予安慰剂联合rh BNP治疗,观察组给予参附注射液联合rh BNP治疗。对比两组治疗期间左心功能[左心室射血分数(LVEF)、血浆BNP及超敏C反应蛋白(hs-CRP)]变化情况及不良反应发生率。结果两组治疗过程中,LVEF指标均呈升高趋势(P<0.05),治疗24周后,观察组LVEF高于对照组(P<0.05);BNP及hs-CRP指标均呈降低趋势(P<0.05或P<0.01),治疗8周、16周及24周后,观察组BNP及hs-CRP均低于对照组(P<0.01);两组药物不良反应发生率比较无明显差异(P>0.05)。结论在ICMHF的治疗过程中,参附注射液联合rh BNP可有效提高临床治疗效果。

Objective To evaluate the treatment efficacy of Shenfu injection combined with recombinant human brain natriuretic peptide（ rh BNP） in Ischemic cardiomyopathy heart failure（ ICMHF）. Methods Seventy-eight cases of patients with ICMHF were randomly divided into two groups,39 in each group. Patients in the control group were given placebo combined with rh BNP treatment while those in the observation group were treated with Shenfu injection combined with rh BNP,respectively,compared two groups of changes of left heart function such as Left Ventricular Ejection Fractions（ LVEF）,plasma BNP and hypersensitive c-reactive protein（ hs-CRP） and the occurrence of adverse reactions in the treatment process were compared between the two groups. Results These showed a trend of increase of LVEF during the treatment process in both groups（ P〈0. 05）. 24 weeks after treatment,LVEF of patients in the observation group was higher than that in the control group（ P〈0. 05） and BNP and hs-CRP in the observation group showed a trend of decrease（ P〈0. 05 or P〈0. 01）. 8 weeks,16 weeks and 24 weeks after treatment,both BNP and hs-CRP in the observation group were lower than those in the control group（ P〈0. 01）. There was no significant difference in the occurrence rates of adverse reactions between the two groups（ P〈0. 05）. Conclusion In the treatment of ICMHF,Shenfu injection combined with rh BNP can effectively improve the clinical effect.