重视非病理因素对ALT测值的影响

Influence of non-pathological factors on ALT measurements

谷丙转氨酶(alanine transaminase,ALT)目前仍是评价肝细胞损伤的最灵敏标志物,但许多非病理因素如不同性别、年龄、妊娠、生活条件、运动、昼夜节律变化、饮食、饮酒、吸烟甚至采血方式、标本采集、传送与保存等,亦直接或间接影响血清ALT等肝酶活性的检测值.临床上应该重视ALT正常值的界定以及某些非病理因素对其检测结果的影响.

Alanine transaminase（ALT） is still the most sensitive marker for evaluating the damage of liver cells. ALT measurements may be affected by common nonpathological factors such as gender, age, pregnancy, different physiological conditions, circadian rhythm, diet, drinking, smoking, strenuous exercise, metabolic factors, drugs, blood collection methods, and specimen collection, transmission, and preservation. It is important to emphasize the definition of limits of normal ALT and the influence of the above-mentioned non-pathological factors on its test results.