Cibenzoline对山羊持续性心房颤动蝉联现象的影响

Effect of cibenzoline on linking phenomenon in chronically instrumented goat model

目的 :分析Ic类抗心律失常药cibenzoline对心房颤动 (房颤 )时蝉联现象的影响。方法 :在 7只山羊的心房缝合心外膜电极 ,用自动房颤刺激器维持房颤 ,待持续性房颤维持 4周后 ,静脉滴注cibenzoline转复房颤。根据激动标测图分析左心房用药前及后蝉联心搏占总心搏数的比例并分析蝉联片段激动方向的规律。结果 :用药前连续 7次循相同路径的激动占 (9 6± 1 5 3) % ,在房颤转复前为 (30 7± 2 6 2 ) % (P <0 0 5) ;用药前后共有 2 7个蝉联片段 ,其激动方向相互垂直的 1 (3 7% )次 ,成 45°角的 2 (7 4% )次 ,一致或相反的 2 3(85 2 % )次 (P <0 0 5)。结论 :I类抗心律失常药cibenzoline可增加房颤时蝉联心搏的比例 。

Objective:To evaluate the effect of Ic antiarrhythmic drug cibenzoline on linking phenomenon in persistent atrial fibrillation goat model Methods: Seven goats were instrumented with atrial electrodes AF was maintained by an automatic atrial fibrillator After 4 weeks of persistent AF, cibenzoline was infused until cardioversion,linking phenomenon in left atrium was studied Results: There were (9 6±15 3)% beats belong to linking episodes before drug infusion, and they were (30 7±26 2)% ( P <0 05)before cardioversion Conclusion: It was found that cibenzoline increased the percentage of linked beats during AF