新疆地区血清抗磷脂酶A2受体抗体阳性肾病患者临床资料分析

Analysis on Clinical Data for 57 Patients of Ser um Anti-phospholipase A2 Receptor (PLA2R) Antibody-positive with Kidney Disease in Xinjiang

目的分析抗PLA2R受体抗体在肾病患者中的检出率及与临床发病特征的相关性。方法采用间接免疫荧光法检测390例肾病患者血清中抗PLA2R受体抗体,以描述方法将检测结果与患者临床资料进行回顾性分析。结果 390例肾病患者中,57例患者抗PLA2R受体抗体阳性,阳性检出率为14.7%。汉族阳性人数多于少数民族。57例阳性患者中与20例接受肾穿患者病理结果比对后诊断膜性肾病符合率为100%。结论间接免疫荧光法检测抗PLA2R受体抗体可作为原发性膜性肾病的疾病特异性标志物,可用于疾病的鉴别诊断,是有潜力的诊断治疗指标。

Objective To analyze the correlation between the detection rate of anti PLA2R receptor antibodies and the clinical characteristics in patients with nephropathy. Methods The anti PLA2R receptor antibodies in serum of 390 patients with renal disease were detected by the indirect immunofluorescence method in the European medical laboratory. Result 390 patients with renal disease,57 patients with anti PLA2R receptor antibody positive, the positiv e detection rate was 14.7%. The number of Han positive is more than that of the minority. 57 cases of positive patients with 20 cases of renal wear patients with pathological results than the diagnosis of membranous nephropathy rate was 100%. Conclusion Indirect immunofluorescence assay for the detection of anti PLA2R receptor antibody as a disease specific marker for primary membranous nephropathy, it can be used for the differential diagnosis of disease, and it is a potential diagnostic index for diagnosis.