无创正压通气治疗重症哮喘的临床观察

Study of Non-invasive Positive Pressure Ventilation in Severe Asthma

目的探讨无创正压通气治疗重症哮喘的效果,为临床应用无创正压通气治疗重症哮喘提供依据。方法回顾性分析2012年6月—2016年6月我院呼吸内科收治的63例重症哮喘患者临床资料,分为研究组33例和对照组30例,两组均给予重症哮喘常规治疗,研究组在此基础上实施无创正压通气治疗,比较两组治疗前后血气指标、肺功能指标改善情况,评价临床疗效及不良反应发生情况。结果研究组治疗3 d后1 s用力呼气容积(FEV1)、用力肺活量FVC、PEF等肺功能指标改善程度均优于对照组,且治疗总有效率较高,差异均有统计学意义(P<0.05)。结论无创正压通气治疗重症哮喘,能够有效改善患者的各项临床指标,具有一定的临床应用价值。

Objective To analyzed clinical effects of NPPV in patients with severe asthma. Methods 63 patients with severe asthma in our hospital fi＇om Jun. 2012 to Jun. 2016 were included in the study. The patients were divided into study group and control group. Control group was treated with conventional therapy, while study group with conventional ther- apy and NPPV. Arterial blood gas, FEV1, FVC and PEF were recorded before treatment and were revaluated 3 days after treatment. Results There was significant improvement in PaO2 , PaCO2 , FEV1, FVC and PEF within 3 days in study group compared with control group, and the total effective rate of treatment is high. The difference was statistically significant （ P 〈 0.05 ）. Conclusion NPPV can effectively improve parameters of arterial blood gas （ PaO：, PaCO2 ） and pulmonary function （FEV1. FVC. PEF） in severe asthma patients.