钙贮库调控的钙通道的药理与分子生物学特征

Pharmacological and molecular biological characteristics of store-operated calcium ciannels

钙贮库调控的钙通道 (store operatedcalciumchannel,SOCC)是指位于细胞膜上的钙离子内流通道 ,当细胞内钙贮库排钙后 ,SOCC被激活开放。目前 ,虽然对SOCC机制以及分子生物学特点等的认识还非常初浅 ,但是 ,由于SOCC广泛地分布于兴奋性和非兴奋性细胞中 ,并且直接参与钙信息传递、基因表达和细胞功能调节等重要过程 ,它的生理和病理意义不容忽视。开发和研制具有高度选择性的SOCC调节药物 ,不仅可以促进实验研究的深入 。

Store operated calcium channels (SOCCs) are referred to as plasma membrane calcium channels that are opened in response to a depletion of intracellular calcium stores. SOCCs are broadly distributed in excitable and non excitable cells, and may play important roles in conducting intracellular calcium signals, modulations of cell functions and gene expression. Although the current understanding of SOCCs related mechanism is still limited, the physiological significance of SOCCs and their possible links to certain diseases have been suggested. Future study of highly selective SOCCs modulating agents may promote not only related research, but also the development of novel therapeutic drugs.