长链非编码RNA H19在肿瘤中的研究进展

Research Progress of Long Nonconding RNA H19 in Cancer

长链非编码RNA是目前肿瘤研究中的热点,在表观遗传学、基因转录和转录后调控等多方面影响肿瘤的发生发展。H19是一个典型的长链非编码RNA,在多种肿瘤中表达异常,而且在不同肿瘤中发挥的作用也不尽相同。同时,H19在肿瘤诊断和治疗方面的研究也显示其具有广泛的应用前景。本文归纳了H19的作用机制,并对其在肿瘤中的作用及在临床肿瘤诊治中的应用作一综述。

Long noncoding RNA（lncRNA） functions in epigenetics,gene transcription and post-transcriptional regulation,and becomes one of highlights in cancer research in recent years.lnc RNA H19 has been found to express abnormally and function differently in a variety of tumors.Studies have suggested that H19 has a wide range of applications in the diagnosis and treatment of cancers. In this article we review the functions and related mechanism of H19 in tumors and also its clinical applications in cancer diagnosis and treatment.