成人髓母细胞瘤的预后相关因素及治疗进展

Progress of Prognostic Factors and Treatment of Adult Medulloblastoma

成人髓母细胞瘤发病率低,手术、术后全脑全脊髓放疗及化疗是主要治疗手段。治疗技术进步使其疗效改善,疾病的组织学类型及分子生物学发展迅速,靶向治疗及免疫治疗是新的治疗手段,其预后因素及治疗方案尚无一致意见,本文就上述两方面做一综述。

The incidence of adult medulloblastoma is infrequent. Surgery,postoperative craniospinal irradiation and chemotherapy are main therapeutic methods. The outcome of medulloblastoma improves because of treatment advances. And with the rapid development of technology in histology types and molecular biology,targeted therapy and immunotherapy become the new cures for medulloblastoma. However,on the issue of prognostic factors and optional treatment,no consensus is reached. The aim of this article is to review the prognostic factors and therapeutic regimens of adult medulloblastoma.