多潘立酮引起心血管疾病不良反应的研究分析

Literature analysis of cardiovascular adverse reactions of domperidone

目的了解由药物多潘立酮所引发的心血管系统不良反应。方法检索中国知网全文数据库、万方数据库、维普数据库、加拿大和英国不良反应自愿报告数据库等,获得关于药物多潘立酮所引发的心血管系统不良反应的文献资料。对相关文献资料进行整理和分析,了解发生不良反应的作用机制及对患者所造成的影响。结果多潘立酮可能导致心脏骤停、室性早搏、室颤、房颤、尖端扭转、心律失常、心肌梗死及心动过速等,引发这些不良反应的相关因素包括用药人群,如:女性多潘立酮导致不良反应的发生率高于男性,中、青年发生率较高。此外,用药剂量不合理、患病情况、联合用药也可能引发不良反应。结论应严格按医师或说明书服用多潘立酮,出现不良反应后应立即停药并进行处理。

Objective To understand the cardiovascular adverse reactions of domperidone. Methods The literatures about cardiovascular adverse reactions of domperidone were collected by searching CNKI,Wanfang database,VIP database and Canadian and British adverse reactions,etc. The collected data was analyzed to learn about the mechanism of adverse reactions and its influence on the patients. Results Domperidone could induce the adverse reactions,such as sudden cardiac arrest,premature ventricular contraction,ventricular fibrillation,atrial fibrillation,cutting-edge reverse,arrhythmia,myocardial infarction,and tachycardia,etc. The related factors that caused the adverse reactions included the objects,such as,the incidence rate of adverse reaction induced by domperidone was higher in female patients or youth and middle-aged patients. In addition,irrational dosage,status of basic disease and combination use of drugs could cause adverse reactions. Conclusion Domperidone should be used strictly according to the prescription or instruction,and the drug has to be stopped and the symptoms should be treated immediately if the adverse reactions occurr.