垂宁方治疗垂体泌乳素型垂体瘤30例

Thirty Cases with Hypophysoma of Pituitary Prolactin Pattern Treated with Chuining Prescription

目的:观察垂宁方治疗垂体泌乳素(pituitary prolactin,PRL)型垂体瘤的临床疗效。方法:将60例PRL型中医辨证为痰湿内阻证的垂体瘤患者随机分为对照组和试验组,每组各30例。对照组服用溴隐亭,试验组服用垂宁方。比较两组患者治疗前后临床症状积分变化情况,观察两组患者治疗前后血清PRL变化情况,采用增强MRI影像学检查垂体动态。结果:对照组有效率为80.00%,试验组有效率为100.00%,两组有效率比较,差异具有统计学意义(P<0.05)。两组患者治疗后临床症状积分低于治疗前,且试验组低于对照组,差异具有统计学意义(P<0.05)。两组患者治疗后PRL将至正常者高于治疗前,且试验组高于对照组,差异具有统计学意义(P<0.05)。治疗后试验组瘤体缩小例数多于对照组,差异具有统计学意义(P<0.05)。结论:垂宁方治疗PRL型辨证为痰湿内阻证垂体瘤,能够有效改善患者的临床症状、降低患者血清PRL水平、缩小垂体瘤瘤体大小、无明显不良反应。

Objective：Tn observe the clinical effects of Chuining Prescription on hypophysoma of pituitary prolactin （PRL） pat- tern. Methods：Totally 60 patients with hypophysoma of PRL pattern differentiated as internal obstruction of phlegm and dampness were randomized into control group and experiment group ,30 cases in each group. Control group were given oral administration of Bromocriptine while experiment group were given Chinese medicine Chuining Prescription. The patients in two groups were con- ducted follow-up and the clinical effects of two groups were compared from the aspects of＂ scores of symptom improvement, changes of the levels of serum PRL, changes of the tumor body indicated by pituitary MRI dynamic enhancement. Results ： In the treatment of 12 months,the differences in the scores of symptom improvement,decline of the levels of serum PRL and changes of the tumor body indicated by pituitary MRI dynamic enhancement between the two groups had statistical significance （ P 〈 0.05 ）. Conclu- sion：For hypophysoma of PRL pattern differentiated as syndrome of internal obstruction of phlegm and dampness, Chuining Pre- scription can effectively and safely improve the clinical symptoms, reduce the levels of serum PRL,lessen the size of hypophysoma without adverse reaction or side effects.