口炎清颗粒对化疗后口腔炎患者口腔疼痛及口腔舒适度的影响

Effects of Kouyanqing Granules on the Pain Relief and Comfort Degree of Patients with Stomatitis After Chemotherapy

目的:观察口炎清颗粒对化疗后口腔炎患者口腔疼痛缓解情况及口腔舒适度的影响。方法:将化疗后出现口腔炎的85例患者按数字表法随机分成两组,口炎清组(43例)给予口炎清颗粒20 g溶于50 mL温开水含服,每天2次。氯己定组(42例)采用复方氯己定含漱液漱口,每次10~20 mL,每天2次。每2天对患者进行观察评估,观察至第8天,内容包括口腔黏膜反应、口腔炎疼痛评价及口腔舒适度评价。结果:口炎清组的口腔炎分级程度低于氯己定组,差异有统计学意义(Mann-Whitney U秩和检验,Z值=-2.281,P<0.05)。口炎清组患者的疼痛评分低于氯己定组,差异有统计学意义(重复测量资料的方差分析,F=1154.7,P<0.01)。口炎清组患者的口腔舒适度评分高于氯己定组,差异有统计学意义(重复测量资料的方差分析,F=183.755,P<0.01)。结论:口炎清颗粒有助于缓解化疗后口腔炎的严重程度和口腔黏膜疼痛程度,提高患者的口腔舒适度和生存质量。

Objective：To observe the influence of Kouyanqing Granules on the pain relief and comfort degree of patients with sto- matitis ＇after chemotherapy. Methods：Totally 85 patients with stomatitis were randomized into Kouyanqing group （43 cases） given Kouyanqing Granules of 20g dissolving in the warm boiled water for oral administration and twice every day and Chlorhexidine group （42 cases） given Chlorhexidine of 10 -20 mL each time for mouthwash and twice a day. Observations and evaluations were conducted for the patients every other day. On the 8th clay, the eontents of oral mueosa reaction, stomatitis pain evaluation and oral comfort degree were evaluated. Results ： The grading degree of stomatitis in Kouyanqing group was lower than that in Chlorhexidine group;the difference had statistical significance （ Mann-Whitney U rank-sum test, Z = - 2. 281, P 〈 0.05 ） ; the pain score of Kouyanqing group was lower than that in Chlorhexidine group,with statistical difference （ F = 1 154.7 ,P 〈0.01 ）. The score of o- ral comfort degree in Kouyanqing group was higher than that in Chlorhexidine group,with statistical difference （F = 183. 755,P 〈 0.01 ）. Conclusion ：Kouyanqing Granules can relieve the severity of the stomatitis and pain degree of oral mucosal pain of patients after chemotherapy,which can improve the patients＇ oral comfort degree and life quality.