摘要
急性坏死性脑病（ANE）是一种罕见的感染后急性脑病，多继发于病毒感染，发病机制可能与宿主感染病毒后产生过度免疫反应有关。其病理改变为局灶性血管损伤所致血脑屏障破坏、血浆渗出，最终引起脑水肿、点状出血、神经元及胶质细胞坏死。影像学改变具有诊断意义，为对称性多灶脑损害，双侧丘脑100％受累。对ANE的治疗无特效药物，主要采用激素、免疫球蛋白和血浆置换等治疗。
Acute necrotizing encephalopathy （ ANE ） is a rare type of acute encephalopathy which occurs secondary to virus infection. Individuals who suffer from ANE usually have an exaggerated immune response to various viral infections. The pathologic change is focal vascular injury which leads to destruction of the blood - brain barrier and vascular permeability that cause brain edema, petechial hemorrhage, and necrosis. The imageological changes of ANE have diagnostic significance which show multifocal, symmetric brain lesions including bilateral thalamus 100% invol- ving. Intravenous g｜ucocorticoids,immunoglobulin, and plasmapheresis should be effective for treatment.
出处
《中华实用儿科临床杂志》
CSCD
北大核心
2017年第24期1848-1853,共6页
Chinese Journal of Applied Clinical Pediatrics
关键词
急性坏死性脑病
诊断
治疗
Acute neerotizing encephalopathy
Diagnosis
Treatment
