动脉自旋标记在儿童脑部疾病中的应用

Application of arterial spin labeling in pediatric brain diseases

动脉自旋标记（ASL）与动态磁敏感对比增强灌注成像不同，其无需对比剂，是一种可重复使用且无创的影像学检查手段。这种技术反转标记流向大脑的动脉血质子，然后用其示踪评价脑灌注。如果所有标记的血液在图像采集时到达成像体素，标记图像和对照图像之间的信号差异将与脑血流量成比例。近年来随着ASL技术的发展，对小儿脑部疾病，如缺氧缺血性脑病、小儿癫痫、小儿脑炎等的诊断有了新的进展。

Arterial spin labeling （ASL）, unlike dynamic magnetic susceptibility contrast enhanced perfusion imaging, does not require contrast agents and it is a reusable and noninvasive imaging approach. This technique reverses the marker flow to the arterial blood protons of the brain and then uses its tracer to evaluate brain perfusion. If all la- beled blood arrive at the imaging voxel at the time of image acquisition, the signal difference between the marker image and the control image will be proportional to the cerebral blood flow. In recent years ,with the development of ASL tech- nology, pediatric brain diseases such as ischemia and hypoxic encephalopathy, pediatric epilepsy, pediatric encephalitis and other diagnosis has made new progress.