中西医结合治疗对急性加重期重症慢性阻塞性肺疾病患者CRP和T细胞亚群的影响

Effect of Integrated Traditional Chinese and Western Medicine on CRP and T Lymphocyte Subsets in Patients with Acute Exacerbation of Severe Chronic Obstructive Pulmonary Disease

目的:探讨中西医结合治疗重症急性加重期重症慢性阻塞性肺疾病的炎症机制。方法:104例急性加重期重症慢性阻塞性肺疾病呼吸衰竭患者随机分为观察组和对照组。对照组采用西医规范治疗,观察组在对照组治疗基础上加用中医辨证治疗。疗程均为14 d,分别于治疗前、第4天、第7天、第14天观察C反应蛋白(C-reactive protein,CRP)、T细胞亚群。结果:与对照组比较,观察组治疗后CRP降低(P<0.05),CD4+无显著差异(P>0.05),CD8+无显著差异(P>0.05),CD4+/CD8+无显著差异(P>0.05)。结论:中西医结合治疗急性加重期重症慢性阻塞性肺疾病可能与降低CRP,改善炎症反应有关。

Objective： To discuss the inflammatory mechanism of respiratory failure patients with acute exacerbating severe chronic obstructive pulmonary diseases by the combined treatment of Chinese and Western medicine. Methods： 104 respiratory failure patients with acute exacerbating severe chronic obstructive pulmonary diseases were divided into the observation group and the control group randomly. The control group was given Western medicine＇ s standard treatment; and the observation group was treated with TCM＇s dialectical treatment additionally. Both groups took 14 days as a treatment course. Observed C-reactive protein（ CRP）and T cell subsets before treatment,and on the 4 th,7 th and 14 th day after treatment. Results： Compared with control group,observation group＇s CRP drops（ P〈0. 05）,CD4＋showed no obvious difference（ P〈0. 05）,CD8＋showed no obvious difference（ P〉0. 05）,CD4＋/CD8＋with no obvious difference（ P〉0. 05）. Conclusion： The combined treatment of Chinese and Western medicine for acute exacerbating severe chronic obstructive pulmonary diseases may be related to CRP drop and improvement of inflammatory reactions.