补肺止咳膏联合舒利迭治疗稳定期慢性阻塞性肺疾病临床研究

Clinical Study of Bufei Zhike Ointment Combined with Seretide in the Treatment of Stable Chronic Obstructive Pulmonary Disease

目的:观察补肺止咳膏对慢性阻塞性肺疾病(chronic obstructive pulmonary disease,COPD)稳定期患者生存质量的影响。方法:120例COPD稳定期患者随机分为观察组和对照组。观察组(60例)予补肺止咳膏联合舒利迭,对照组(60例)以舒利迭治疗,疗程均为180 d。观察治疗前后主要症状评分、肺功能以及6分钟步行试验(6 minute walk test,6MWT)情况。结果:治疗前后比较,观察组主要症状(咳嗽、咯痰、气短、喘息)评分均有明显下降(P<0.05);治疗后两组间比较,观察组以上症状评分均低于对照组(P<0.05)。观察组肺功能第1秒用力呼气容积(forced expiratory volume in one second,FEV1)占用力肺活量(forced vital capacity,FVC)百分比(FEV1/FVC%)显著升高(P<0.05),观察组FEV1/FVC%高于对照组(P<0.05);观察组治疗后6MWT积分低于治疗前(P<0.05),低于对照组(P<0.05)。结论:补肺止咳膏联合舒利迭能更好改善COPD稳定期患者生存质量。

Objective： To observe the effect of Bufei Zhike ointment on the quality of life in patients with stable chronic obstructive pulmonary disease（ COPD）. Methods： 120 cases of patients with stable COPD were randomly divided into the observation group and the control group,each of 60 cases. The observation group was given Bufei Zhike ointment combined with Seretide,and the control group was given Seretide treatment,and 180 d as a course of treatment. The main symptom scores,pulmonary function and6 minute walk test（ 6 MWT） were observed before and after treatment. Results： After treatment,the main symptoms（ cough,expectoration,shortness of breath,wheezing） scores of the observation group were significantly decreased（ P〈0. 05）; comparison between the two groups after treatment,above symptom scores in the observation group were lower than the control group（ P〈0. 05）. Lung function forced expiratory volume in one second of the observation group accounting for forced vital capacity（ FVC）percentage（ FEV1/FVC%） increased significantly（ P〈0. 05）,FEV1/FVC% of the observation group was higher than that of the control group（ P〈0. 05）. After treatment,6 MWT score in the observation group lower than before treatment（ P〈0. 05）,lower than that of the control group（ P〈0. 05）. Conclusion： Bufei Zhike ointment combined with Seretide can improve the quality of life in patients with stable COPD.