HIV感染与细胞焦亡

HIV infection and pyroptosis

目前艾滋病(AIDS)被认为是一种慢性疾病。炎症和免疫活化在疾病进展中起了重要作用。细胞焦亡是HIV感染过程中造成CD4^+T细胞死亡的主要程序性细胞死亡方式,并伴随着IL-1β等促炎因子和细胞内容物的释放,引起机体炎症反应。细胞焦亡联系起了HIV感染过程中的CD4^+T细胞死亡和炎症反应发生这2个最主要的病理事件。因此,抑制细胞焦亡可能对艾滋患者的治疗有重要意义。本文综述了HIV感染过程中细胞焦亡的发生及其引起的病理性事件,为探索艾滋病患者治疗新策略提供线索。

AIDS is considered to be a chronic disease, inflammation and immune activation in which played an important role. Pyroptosis is the most important mechanism to account for the CD4 ＋ T cells depletion after HIV infection accompanied by releasing inflammatory factors and cell contents. Pyroptosis link the two pathogenic signatures of HIV infection through a common mechanistic pathway： the death of CD4 T cell and chronic inflammation. Therefore, inhibition of pyroptosis may be important for the treatment of HIV/AIDS patients. This paper reviews the molecular mechanism and pathological events of pyroptosis during HIV infection to provide clues of new treatment strategies for AIDS patients.