不同离体组织射频消融气化范围的对比研究

An in vitro Comparative Study of Gasification Induced by Radiofrequency Ablation in Different Tissues

目的通过对离体猪肌肉组织和肝组织进行射频消融,探讨气化范围与时间和功率间的关系以及不同组织气化范围间的差异。方法分别对新鲜猪肌肉组织、肝组织行射频消融,超声下测量并计算气化范围最大切面的体积,以对比不同时间和功率下气化范围的大小。实验重复3次,并取平均值。结果一定范围内,随消融时间及功率的增加,各组织气化范围显著增加(P<0.05)。相同时间、相同功率射频消融时,不同组织消融的气化范围有统计学差异(P<0.05)。功率为15和30 W时,肌肉组织消融的气化范围显著小于肝组织(P<0.05),而消融功率为45 W时,肌肉组织消融的气化范围显著大于肝组织(P<0.05)。结论消融时间和功率相同情况下,不同组织消融的气化范围不同,不同组织产生最大气化范围所需的功率和时间可能不同。

Objective To investigate the association between gasification and duration and power of radiofrequency ablation in porcine muscle and liver and compare the effects in these tissues in an in vitro study. Methods Radiofrequency ablation was performed on fresh muscle and liver tissue, and the maximum cross-sectional volume of gasification was used to compare the effects according to duration and power of ablation. The experiment was repeated three times, and data were averaged. Results Within a certain range, gasification volume increased significantly with increases in ablation duration and power （P 〈 0.05）. Gasification volumes differed significantly between tis- sues （P 〈 0.05）. The gasification volume was smaller in muscle than in liver at 15 W and 30 W,while the affected volume in muscle was greater than in liver at 45 W （P 〈 0.05）. Conclusion Under conditions of the same duration and power,the gasification volumes were different in muscle and liver. Therefore, the power and time required for maximum gasification in different tissues may be different.