2型糖尿病患者血清尿酸及尿微量白蛋白水平与慢性血管并发症的相关性

Correlation of Serum Uric Acid and Microalbuminuria with Chronic Vascular Disease in Type 2 Diabetes Mellitus

目的评估2型糖尿病患者(T2DM)血清尿酸(SUA)及尿微量白蛋白(MAU)水平与慢性血管并发症的相关性。方法研究共纳入892例T2DM患者。慢性血管并发症包括冠状动脉疾病(CAD)、脑血管疾病(CVD)、糖尿病肾病(DN)、糖尿病视网膜病变(DR)和糖尿病周围神经病变(DPN)。结果随着SUA和MAU水平的升高,慢性血管并发症的发生率逐渐升高。SUA的水平与CAD、CVD、DN、DR、DPN以及总慢性血管发生率呈正相关,而MAU的水平与CAD、CVD、DR、DPN以及总慢性血管发生率呈正相关。多因素逻辑回归分析显示,患者SUA水平可以独立预测CAD、CVD、DN、DR、DPN以及总慢性血管疾病的发生风险,而MAU水平可以独立预测CAD和CVD的发生风险。结论 SUA和MAU水平可以作为T2DM患者慢性血管并发症发生风险的可信的预测标志物。

Objective To assess the correlation of serum uric acid （SUA） and microalbuminuria （MAU） with chronic vascular disease in type 2 diabetes mellitus （ T2DM）. Methods The study enrolled 892 T2DM patients. The association of different SUA and MAU levels with the incidence of chronic vascular disease was evaluated. Chronic vascular disease included coronary artery disease （CAD） , eere- brovascular disease （CVD） , diabetic nephropathy （DN） , diabetic retinopathy （DR） , and diabetic peripheral neuropathy （DPN）. Results With increasing levels of SUA and MAU, the incidence of chronic vascular disease increased. In addition, the level of SUA was positively correlated with the incidence of CAD, CVD, DN, DR, DPN, and total chronic vascular disease, while the MAU level was positively asso- ciated with the incidence of CAD, CVD, DR, DPN, and total chronic vascular disease. Multivariate logistic regression analysis revealed that SUA level was an independent predictive risk factor for patients with concurrent CAD, CVD, DN, DR, DPN, and total chronic vascular disease, and MAU level independently predicted the risk of CAD and CVD. Conclusion The levels of SUA and MAU may be reliable hiomarkers for prediction of the risk of chronic vascular disease in T2DM patients.