特发性膜性肾病的中医药实验研究进展

Experimental research progress of TCM on treating idiopathic membranous nephropathy

特发性膜性肾病是原发性肾病综合征最常见的病理类型之一,足细胞损伤是主要的发病机制,中医药治疗具有独特优势。文章就近年来中医药治疗特发性膜性肾病的实验研究进展作一综述。中医药实验研究普遍采用疾病模型,病证结合模型应用较少。取效机制是目前本病中医药实验研究的重心。在研究成果方面,中药复方、单味中药及中药有效成分在保护足细胞、改善高凝状态、减轻肾纤维化、抑制免疫反应、缓解激素副作用等方面均有较好的体现。

Idiopathic membranous nephropathy is one of the most common pathological types of refractory nephrotic syndrome and its main mechanism is podocyte injury. Traditional Chinese medicine treatment has unique advantages. This article summarizes the experimental research progress on treating idiopathic membranous nephropathy with TCM in recent years. The animal models of disease are widely used, however, application of the combination of disease and syndrome animal model are used less. The core of experimental research is mechanism of effects exploration. In the research results, Chinese herbal compound prescriptions, single Chinese herbs and effective components of Chinese herbs have a good manifestation in protecting podocyte, improving high condensation, reducing renal fibrosis, inhibiting immune response and relief side-effects of hormone.