川崎病患儿炎症因子和免疫功能指标检测的临床意义

Detection of Inflammatory Factors and Immune Function Indexs in Children with Kawasaki

目的:探讨川崎病患儿炎症因子和免疫功能指标的变化及意义。方法:选取2013年1月至2017年1月在我院儿科住院治疗的川崎病患儿78例作为川崎病组,同期在我院儿科住院的非川崎病患儿82例作为非川崎病组,同期在我院门诊体检的健康儿童75例作为对照组。检测三组儿童的炎症因子及免疫功能指标,其中川崎病组患儿分别在急性期和亚急性期各检测一次,比较分析检测结果。结果:川崎病组患儿急性期CRP、IL-1β、IL-6、IL-8、TNF-α水平明显升高,亚急性期开始降低,但仍均高于对照组(P均<0.05);亚急性期CRP、IL-1β、IL-6、IL-8、TNF-α水平与非川崎病组比较,差异均无统计学意义(P均>0.05);急性期CD3+、CD8+、NK细胞水平明显降低,亚急性期开始升高,但仍均低于对照组和非川崎病组(P均<0.05);急性期CD4+、CD4+/CD8+、Ig G、Ig A、Ig M水平明显升高,亚急性期开始降低,但仍高于对照组和非川崎病组(P均<0.05)。结论:川崎病患儿存在炎症因子和免疫功能指标异常,CD3+、CD8+、NK细胞、CD4+、CD4+/CD8+、Ig G、Ig A、Ig M可以作为诊断川崎病的实验室指标,而CRP、IL-1β、IL-6、IL-8、TNF-α仅可考虑作为川崎病患儿急性期的实验室诊断指标。

Objective： To investigate the changes and significance of inflammatory factors and immune function indexes in children with Kawasaki. Methods： Seventy-eight children with Kawasaki disease were selected as the Kawasaki disease group,82 cases of the same period in the hospital with non Kawasaki disease as non Kawasaki disease group,then 75 healthy children were selected as control group. Inflammatory factors and immune function indexes of three groups were detected,Kawasaki disease group was detected in acute and subacute stage. Results： CRP,IL-1β,IL-6,IL-8,TNF-α levels of Kawasaki disease in children with acute stage increased significantly,in subacute stage began to decrease,but still higher than those of the control group（ P0. 05）. There were no significant differences between Kawasaki disease group in subacute stage and non Kawasaki disease group in CRP,IL-6,IL-1β,IL-8,TNF-αlevels（ P0. 05）. The CD3＋,CD8＋,NK cells of Kawasaki disease group in acute phase decreased,in subacute stage began to rise,but still lower than the control group and non Kawasaki disease group（ P 0. 05）. The levels of CD4＋,CD4＋/CD8＋,Ig G,Ig A,Ig M in acute stage were significantly elevated,in subacute stage started to decrease,but still higher than the control group and non Kawasaki disease group（ P0. 05）. Conclusion： The children with Kawasaki disease have abnormal inflammatory factors and immune function indexes,CD3＋,CD8＋,NK cells,CD4＋,CD4＋/CD8＋,Ig G,Ig A,Ig M can be used as laboratory indexes in the diagnosis of Kawasaki disease. CRP,IL-6,IL-8,IL-1β,TNF-α applies can only use as diagnostic indexes in children with acute stage of Kawasaki disease.