白塞病96例临床分析

A retrospective analysis of 96 cases of Behcet's disease

目的:分析96例白塞病的临床特点。方法:回顾性分析96例白塞病住院患者的临床表现及实验室检查等资料,并分析不同性别、不同年龄段及各年龄段不同性别各系统受累的发病率。结果:96例患者中男女比例为1∶1.1,平均年龄(39.60±13.03)岁;平均病程(4.38±5.45)年。口腔溃疡发生率为94.8%,生殖器溃疡为59.4%,结节性红斑为55.2%,毛囊炎为35.4%,皮肤针刺反应阳性为22.9%,眼部损害为55.2%,关节受累为38.5%,血管受累为10.4%,神经系统受累为8.3%,消化系统受累为7.3%,呼吸系统受累10.4%,心脏受累为6.3%。女性结节性红斑较男性多见(P<0.05),且无论在青年、中年及老年年龄组,女性结节性红斑发病率均高于男性;男性眼部受累及血管受累均高于女性(P均<0.05);毛囊炎在青中年组发病率高于老年组(P<0.05),且中青年组男性患者明显多于女性(P<0.05)。实验室检查示外周血WBC增高为17.0%,中性粒细胞比例增高为38.3%,红细胞沉降率(ESR)增高为27.1%,C反应蛋白(CRP)增高为42.7%,尿蛋白增高为35.1%,尿糖升高为8.51%,Ig A增高为22.5%,Ig M增高为10.0%,抗核抗体(ANA)阳性9.1%,抗双链(ds)-DNA抗体均阴性。结论:白塞病临床表现多样,可累及多个器官和系统,但其某些临床表现的发生率可能因性别、年龄及各年龄组不同性别的差异而不相同。

Objective： To summarize and analyze the clinical features of Behcet＇s disease in Gansu Province. Methods： The clinical manifestations and laboratory tests were retrospectively analyzed in 96 hospitalized patients with Behcet＇s disease. The incidences of systemic involvement in different genders and age groups were analyzed. Results： The male to female ratio was 1：1.1; The mean age was（39.60±13.03） years, and the average duration of disease was（4.38±5.45） years. The incidences of clinical manifestations arranged in descending order were oral ulcers（94.8%）, genital ulcers（59.4%）, erythema nodosum（55.2%）, ocular involvement（55.2%）, joint involvement（38.5%）, folliculitis （35.4%）, positive pathergy test （22.9%）, vascular involvement（10.4%）, the respiratory system（10.4%）, nervous system（8.3%）, digestive system（7.3%）, cardiac involvement in 6.3%. Erythema nodosum was more common in the females than in the males regardless of the ages （P〈0.05）. Ocular and vascular involvements were more frequent in the males than in the females（P〈0.05）. Incidences of folliculitis in the young and middle-aged groups were higher than that in the elderly （P〈0.05）, with a higher incidence in the males than in the females in young group （P〈0.05）. Laboratory findings included elevation in peripheral blood leukocytes （17%）, neutrophila （38.3%）, elevated ESR （27.1%）, elevated CRP level （42.7%）, proteinuria （35.1% ）, elevated UGLU level（8.51%）, elevated IgA level（22.5%）, elevated lgM level（10.0%）, and elevated anti-ANA antibody level（9.1%） with no changes in anti-ds-DNA antibody. Conclusions： Behcet＇s disease can involve multiple organs and systems, and exhibits diverse clinical manifestations. The clinical manifestations vary with gender, age, and geographical location.