慢性特发性荨麻疹患者血清中维生素D水平检测及其临床意义

Assessment of serum levels of vitamin D and its significance in patients with chronic idiopathic urticaria

目的:检测慢性特发性荨麻疹(CIU)患者血清中维生素D水平变化并评估其临床意义。方法:采用酶联免疫吸附法(ELISA)测定126例CIU患者(CIU组)及88例健康人(对照组)外周血血清中25-羟基维生素D[25-(OH)D]水平,并检测2组受试者血清中总IgE水平。结果:CIU组外周血血清中25-(OH)D水平[(39.18±1.63)nmol/L],较对照组[(65.91±1.92)nmol/L]明显降低(P<0.01)。CIU组外周血血清中总IgE水平[(151.31±18.92)g/L],较对照组[(25.76±9.45)g/L]明显增高(P<0.01)。CIU患者血清中25-(OH)D水平与总IgE水平呈负相关(r=-0.787,P<0.01),与荨麻疹活动评分呈负相关(r=-0.686,P<0.01)。结论:CIU组血清中维生素D水平下降;维生素D缺乏可能与CIU的发病相关。

Objective： To measure the serum levels of 25-（OH）D in patients with chronic idiopathic urticaria（CIU） and to determine the relationship between vitamin D levels and patients＇ susceptibility to CIU, Methods： The serum levels of 25- hydroxyvitamin D[25-（OH）D] and total IgE levels were measured in 126 patients with CIU and 88 healthy controls,using enzyme-linked immunosorbent assay（ELISA）. Results： Serum 25-（OH）D levels decreased significantly in the CIU group com- pared with those in the controls（39.18±1.63 nmol/L vs. 65.91±1.92nmol/L, P〈0.01）. In contrast, total serum IgE levels increased significantly in the CIU group compared with those in the controls （151.31±18.92 g/L vs. 25.76±9.45 g/L, P〈0.01）. Serum 25-（OH）D levels were negatively correlated with total serum IgE levels in CIU patients（r=-0.787, P〈0.01）, and negatively correlated with urticaria activity scores（r=-0.686, P〈0.01）. Conclusions： Patients with CIU have significantly lower levels of vitamin D. Vitamin D deficiency may be related to the occurrence of CIU.