毛囊角化病14例临床分析

Clinical analysis of 14 cases of keratosis follicularis

目的:分析14例毛囊性角化病的临床表现及组织病理特点。方法:回顾性分析14例毛囊性角化病患者临床表现、组织病理及疗效等。结果:14例患者中男8例,女6例,平均发病年龄(12.86±4.36)岁。皮损表现为皮脂溢出部位的丘疹上覆油腻性结痂,可伴有指甲V字形缺损。该病典型的组织病理表现为基底层上裂隙和角化不良细胞。结论:该病可根据临床表现和组织病理确诊,予口服阿维A及维生素E软胶囊,外用他扎罗汀乳膏等治疗,疗效较好。

Objective： To analyze the clinical manifestations and histopathological features of keratosis follicularis. Method： The clinical manifestation, histopathological features and therapeutic responses were retrospectively analyzed in 14 patients, including 8 males and 6 females, with follicular keratosis. Results： The average age of onset was 12.86±4.36 years old. Clinical manifestations included oily crusts on the papules on the seborrheic areas. Usually a V-shape defect could be found in the nail Suprabasilar cleavage and dyskeratosis were the typical histopathological characteristics. Conclusions： Keratosis follicularis can be diagnosed according to clinical manifestations and histopathology. Oral acitretin capsules and vitamin E soft capsules, and topical tazarotene cream are effective.