痛风患者伴发病回顾性研究

Retrospective study of comorbidities in patients with gout

目的探讨痛风与高血压、糖尿病、血脂异常等伴发病的关系。方法回顾性分析2013年6月至2015年12月第三军医大学第三附属医院收治187例痛风患者临床资料,根据病程、有无痛风石、有无肾结石分组探讨伴发病与痛风的关系。结果最常见的伴发病是血脂异常(51.45%),其次是高血压(46.52%)、骨关节炎(43.09%)、脂肪肝(42.19%)、肾结石(35.90%)、肾功受损(23.53%)和糖尿病(16.58%)。病程大于或等于10年痛风患者更容易出现痛风石、肾功能受损、高血压及骨关节炎(P<0.05);有痛风石患者血尿酸水平更高,更容易出现肾功受损和骨关节炎(P<0.05);有肾结石与无肾结石两组患者伴发病的患病率差异无统计学意义(P>0.05)。结论痛风患者伴发病的患病率高,发病年龄越小、病程越长、年龄越大或出现痛风石的痛风患者更容易出现伴发病。

Objective To explore the relationship between gout and its comorbidities such as hypertension,diabetes and dys- lipidaemia. Methods The clinical data in 187 cases of gout admitted in the Third Affiliated Hospital of the Third Military Medical University from June 2013 to December 2015 were retrospectively analyzed. The patients were grouped according to the disease course, with or without tophi and nephrolithiasis. Then the relationship between gout and its comorbidities was investigated. Results The most common comorbidity of gout was dyslipidaemia （51. 45%）, followed by hypertension （46. 52%）, osteoarthritis （43.09%） ,fatty liver（42.19%）,kidney stone（35.90%）, renal dysfunction（23.53%） and diabetes（16.58%）. The patients with longer disease duration（-10 years） were more likely to suffer higher prevalence of tophi, renal dysfunction,hypertension and osteo- arthritis. Furthermore, the patients with tophi demonstrated remarkably higher levels of serum uric acid and greater prevalence of renal dysfunction and osteoarthritis than those without tophi. In addition,the prevalence rate of comorbidities had no difference between the patients with and without kidney stones. Conclusion The patients with gout have higher morbidity rate of comorbidities. Gout patients with younger onset age,longer disease duration,older age or tophi are more likelv to present with comorbidities.