益生菌对胃癌术后感染并发症以及术后恢复的影响

Effect of Probiotics on Postoperative Infections and Recovery in Gastric Cancer Patients after Surgery

目的探讨益生菌对胃癌患者术后感染并发症的发生以及术后恢复的影响。方法纳入择期手术的胃癌患者共119例,随机分为对照组60例和试验组59例。两组患者采取常规术前准备以及术后处置,试验组在此基础上加用益生菌治疗。分别对两组患者的术后感染并发症发生情况、腹泻和便秘发生情况、血清CRP水平和前白蛋白水平、术后排气时间及住院时间进行记录并比较。结果试验组发生术后感染以及腹泻、便秘症状的例数均少于对照组,差异有统计学意义(P值分别为0.043及0.007);试验组术后第7天血清CRP水平低于对照组(P<0.01);两组前白蛋白水平在3个时间点(术前1天、术后第3天及术后第7天)均没有差异(P>0.05),但在术后第7天试验组的前白蛋白水平略高于对照组;试验组的术后首次排气时间及住院时间均早于对照组。结论与应用常规术前准备及术后处置的对照组相比,应用益生菌能减少术后感染并发症的发生,并能促进术后胃肠道功能的恢复。

Objective To evaluate the effect of probiotics on postoperative infectious complications and recovery in gas- tric cancer （GC） patients after surgery. Methods A total of 119 GC patients underwent surgery were divided into the test group and the control group after surgery randomly. Both of the 2 groups were assigned to receive the standard GC treatment. The test group received probiotics treatment additionally. The effect of standard GC treatment combined with probiotics on the reduction of complications and postoperative recovery was evaluated. Results The incidence of infections was significantly lower （ P = 0. 043 ） in the test group ; the incidence of diarrhea and constipation was also lower in the test group compared with the control group（ P = 0.007）. CRP level was lower in the test group on POD7 （P 〈 0.01 ） ;patients in the test group have earlier bowel movement than the control group and the length of hospital stay was shorter significantly（P 〈 0.01 ）. Conclusion The use of probiotics can re- duce the rate of postoperative infections and enhance the recovery after gastric cancer surgery.