不同放疗方法治疗宫颈癌的临床观察

Effects of Different Radiotherapy on Cervical Cancer

目的探讨不同放疗方法治疗宫颈癌的临床效果及安全性。方法选择宫颈癌患者108例,根据随机信封抽签原则分为观察组与对照组,各54例。对照组给予常规放疗,观察组给予三维适形调强放疗。2组都治疗观察3个月,记录2组预后情况。结果放疗后观察组与对照组的有效率分别为81.5%和63.0%,观察组的放疗有效率明显高于对照组(P<0.05)。放疗期间观察组的皮肤损伤、胃肠道反应、放射性膀胱炎、血液系统异常等不良反应情况明显少于对照组(P<0.05)。所有患者随访至今,观察组与对照组的中位生存时间分别为(35.32±4.19)个月和(22.49±3.78)个月,观察组明显长于对照组(t=7.221,P<0.05)。结论相对于常规放疗,三维适形调强放疗在宫颈癌的应用能达到更好的靶区分布和降低危及器官的受照射体积,从而减少不良反应的发生,提高治疗效果,延长患者的生存时间。

Objective To study the effects of different radiotherapy on cervical cancer. Methods 108 cervical cancer patients were selected and were divided into observation group and control group of 54 patients, The control group was received routine radiotherapy, the observation group was treated with three dimensional conformal radiation therapy. The 2 groups were trea- ted for 3 months,and the prognosis of the 2 groups were recorded. Results The effective rate of the observation group and the control group were 81.5 % and 63.0% respectively, and the effective rate of the observation group was significantly higher than that of the control group （ P 〈 0.05 ）. During radiotherapy, the adverse reactions such as the skin damage, gastrointestinal reaction, radiation cystitis, abnormal blood system of the observation group were significantly less than those of the control group （P 〈 0.05 ）. All patients were followed up so far,the median survival time of the observation group and the control group were 35.32 ＋ 4.19 months and 22.49 ＋3.78 months,the observation group was significantly longer than the control group（t = 7. 221 ,P 〈 0.05）. Conclusion Compared with conventional radiotherapy, three dimensional conformal radiotherapy in cervical cancer can achieve better target distribution and reduce the oar irradiation volume, thereby reduce the adverse reaction, improve the therapeu- tic effect, prolong the survival time of patients.