重组牛碱性成纤维细胞生长因子外用凝胶用于舌癌术后放疗患者口腔溃疡的效果分析

Analysis of Recombinant Bovine Basic Fibroblast Growth Factor Topical Gel for Tongue Cancer Patients Treated with Radiotherapy Effect of Oral Ulcers

目的分析重组牛碱性成纤维细胞生长因子外用凝胶用于舌癌术后放疗患者口腔溃疡疗效。方法选取80例舌癌术后放疗的患者,按照使用药物的不同,分为对照组(给予阿莫灵+复合维生素B+冰硼散)38例、观察组(阿莫灵+复合维生素B+重组牛碱性成纤维细胞生长因子外用凝胶)42例。结果经过对比分析,两组患者治疗前口腔溃疡0~Ⅳ各级患者例数没有明显的差异(P>0.05);经过放疗后干预,两组患者在9天内得到了好转;1~2天时,观察组好转例数占38.10%,对照组占13.16%;3~5天时,观察组好转例数占26.19%,而对照组为15.79%;6~8天时,好转例数观察组与对照组相同;前5天内,观察组明显优于对照组,组间差异明显(P<0.05)。两组患者接受不同的药物干预后,其疗效存在显著差异,观察组总有效率为95.23%,而对照组为81.58%,具有统计学意义(P<0.05)。结论重组牛碱性成纤维细胞生长因子外用凝胶用于舌癌放疗后患者,可以有效降低口腔溃疡的发生率,提高生存质量。

Objective To analyze the effects of recombinant bovine basic fibroblast growth factor topical gel for oral tongue cancer radiotherapy ulcer patients. Methods 80 patients with tongue cancer treated with postoperative radiotherapy, ac- cording to different use of drugs ,were divided into the control group （ 38 cases administered amoxicillin ＋ Ling complex vitamins B ＋ Bingpeng） and the observation group （42 cases treated with amoxicillin ＋ Ling complex vitamins B ＋ into recombinant bovine basic fibroblast growth factor topical gel）. Results Before treatment, there had no significant difference in the number of patients with stage 0 - IV oral ulcers （ P 〉 O. 05 ） ; Intervention after treatment with radiotherapy, both groups were improved in 9 days. In 1 ~ 2 days,improvement cases in the observation group accounted for 38.10%, the control group was 13.16% ;after 3 -5 days, improvement cases in the observation group accounted for 26.19%, the control group was 15.79%. After 6 ~ 8 days, improvement cases in the 2 groups were the same. In first 5 days, the observation group was superior to the control group, there had a significant difference between the 2 groups, （P 〈 0.05 ）. After the patients of the 2 groups received different drug intervention, total effective rate of the observation group was 95.23% ,while the control group was 81.58% ,there had a significant difference between the 2 groups （ P 〈 0. 05 ）. Conclusion The recombinant bovine basic fibroblast growth factor topical gel for tongue cancer patients after radiotherapy can effectively reduce the incidence of oral ulcers and improve quality of life.