达英35治疗青春期功血的疗效观察

Study of therapeutic efficacy of Diane-35 in adolescent DUB patients

目的 通过临床试验,观察达英-35治疗青春期功血的疗效、不良反应、治疗特点等.方法 收集2012年1月至2014年11月本院妇科收治的青春期功血患者122例,分为观察组和对照组.观察组使用达英-35进行治疗,对照组使用补佳乐＋安宫黄体酮序贯治疗,观察两组治疗效果.结果 观察组急性期止血效果优于对照组（P〈0.01）,差异有极显著性意义.观察组阴道流血减少时间和阴道流血停止时间均短于对照组,差异有显著性意义（P〈0.05）.两组患者治疗后的月经恢复情况比较,观察组优于对照组（P〈0.05）,差异有显著性意义.在不良反应的观察中,观察组的不良反应发生率为3.3%,对照组不良反应发生率为22.95%,观察组低于对照组（P〈0.05）,差异有显著性意义.结论 本研究观察达英-35治疗青春期功血的临床疗效,得出达英-35在急性期的止血效果优于补佳乐,且达英-35止血起效时间快、不良反应少,观察随访发现其调经作用较补佳乐＋安宫黄体酮序贯疗法更稳定.

Objective To observe the efficacy of Diane-35 in treating adolescent DUB patients,as well as the adverse reactions and characteristics of Dane-35.Methods Selected 122 cases of adolescent DUB patients admitted to our hospital′s gynecology from January 2012 to November 2014.Divided those 122 cases into two groups：the observation group and the control group.Observation group were treated using Diane-35,while the control group using progynova ＋ medroxyprogesterone sequential therapy.Results In the acute phase,Dane-35′s hemostas was better than the control group （P〈0.01）,showing significant difference.The time of vaginal bleeding becoming less and vaginal bleeding stop in observation group were both shorter than the control group,the differ-ence was significant （P〈0.05）.We compared the two groups of patients′menstrual recovery and found that the observation group was better than the control group （P〈0.05）,the difference was significant.We also compared the adverse reactions in two groups and found that the the incidence of adverse events in the observation group was 3.3% while the incidence in control group was 22. 95%,showing significant difference （P〈0.05）.Conclusion This study investigated the clinical efficacy of Diane-35 in adolescent DUB.We draw Diane-35 hemostasis was better than progynova in the acute phase.Also Dane-35 was faster in acting than progyno-va,and its adverse reaction was lesser than progynova.The effect of Dane-35 on menstruation was more stable than progynova ＋medroxyprogesterone sequential therapy.