上海宝山地区健康成人血清总胆红素参考区间的建立及验证

Establishment and validation of reference interval for serum total bilirubin in healthy adults in Baoshan ,Shanghai

目的 建立上海宝山地区健康成人（18~60岁）血清总胆红素的参考区间.方法 选取2016年1~12月在本院健康体检人群,结合问卷、体检数据及实验室检查等排除用药、肝胆性疾病、代谢性疾病等不合格个体,将合格的健康者按性别进行分组分析.结果 数据经SPSS19.0统计软件分析,本地区成人血清总胆红素参考区间男性为（5.5~29.2）umol/L,女性为（6.7~26.9）umol/L,与现行实验室参考区间比较（P〈0.01）有统计学意义.结论.

Objective To set up the reference range of serum total bilirubin for healthy adults （18 to 60 years old）of Shanghai baoshan district.Methods Select health check-up population of our hospital from Jan.to Dec.2016,combining questionnaire,physi-cal examination and laboratory examination data to rule out unqualified individuals,such as medicine,liver disease,metabolic disea-ses,etc,and then analyze qualified healthy individuals by gender group.Results The data was analyzed statistically by SPSS19.0 software,IN our district,The reference range of serum total bilirubin for healthy male（5.5~29.2）umol/L,for women （6.7~26. 9）umol/L,compared with the current lab reference range （P〈0.01）,it was statistically significant.Conclusion Existing reference interval for labhas been unable to cover the 95% normal serum total bilirubin concentrations of individual distribution range,it is necessary to set up the reference range of serum total bilirubin for different gender of our district.