摘要
寡肽转运蛋白1(oligopeptide transporter 1,PepT1;solute carrier family 15 member 1,SLC15A1)是一种主要存在于小肠上皮细胞的质子依赖型转运蛋白质,转运底物主要为蛋白质水解产物中的二肽、三肽以及与二肽、三肽结构类似的一些化合物。PepT1的研究有助于促进药物生物利用度的提高,对于肿瘤的治疗也具有十分重要的意义。现主要从PepT1的晶体结构、靶向前药、转运底物、相互作用的蛋白质及PepT1的疾病应答机制等几方面展开综述。
Oligopeptide transporter 1 （PepT1）, a proton-dependent transporter, is widely distributed in intestinal epithelial cells. PepT1 is responsible for the transport of dipeptides, tripeptides and their analogues, all of which originate from the digestion of proteins. The investigation on PepT1 is of great advantage to improve the bioavailability of drugs, especially those for the treatment of cancer. Here, the crystal structure, prodrugs, substrates, interaction proteins of PepT1, as well as its response to diseases were reviewed.
出处
《生命科学研究》
CAS
CSCD
2017年第6期542-546,共5页
Life Science Research
