姜黄素及其类似物心血管保护作用研究进展

The Beneficial Role of Curcumin and its Analogues in Cardiovascular Diseases

姜黄素(Diferuloylmethane)是咖喱香料姜黄中的一种黄色多酚。它已被用于在各种传统医学疾病。现代科学的研究已经证明其具有抗炎,抗氧化,抗癌,抗血栓形成和心血管保护作用。该综述主要集中在姜黄素对心血管系统的影响。姜黄素具有抗氧化作用,减弱阿霉素的心脏毒性,并且可以防止糖尿病的心血管并发症。在动物模型已经证实姜黄素通过抑制P300-HAT来改善心脏肥大和心脏衰竭的发展。姜黄素的抗炎作用可能具有预防房性心律失常作用,其调整Ca^(2+)稳态的作用可能在预防室性心律失常发挥作用。该综述从动物到人类临床数据进行了讨论。

Curcumin(diferuloylmethane) is a polyphenol responsible for the yellow color of the curry spice turmeric.It has been used in a variety of diseases in traditional medicine.Modern scientific research has demonstrated its anti-inflammatory,anti-oxidant,anti-carcinogenic,anti-thrombotic,and cardiovascular protective effects.In this review,we focused mainly on the effects of curcumin on the cardiovascular system.The antioxidant effects of curcumin have been shown to attenuate adriamycin-induced cardiotoxicity and may prevent diabetic cardiovascular complications.The p300-HAT inhibitory effects of curcumin have been demonstrated to ameliorate the development of cardiac hypertrophy and heart failure in animal models.The inflammatory effects of curcumin may have the possibility of preventing atrial arrhythmias and the possible effect of curcumin for correcting the Ca2 +homeostasis may play a role in the prevention of some ventricular arrhythmias.The preclinical studies from animal to clinical data in human are discussed.