肺癌患者肿瘤异常糖链蛋白的表达及其意义

Expression and clinical significance of TAP in lung cancer patients

目的探讨肺癌患者血浆肿瘤异常糖链蛋白(TAP)的表达及其临床意义。方法采用酶联免疫法检测93例肺癌患者及100例健康体检者血浆TAP浓度。结果肺癌组血浆TAP浓度明显高于健康对照组[(187.71±82.295)μm^2 vs.(67.836±28.642)μm^2,t=13.991,P<0.05],TAP在肺癌组的灵敏度83.87%。结论 TAP检测可以提高肺癌患者的早期诊断率,对其早期诊断、早期治疗有重要意义,适用于健康人和高危人群的肺癌筛查。

Objective To investigate the expression and clinical significance of tumor abnormal protein （TAP）in patients with lung cancer.Methods Plasma TAP concentration was measured by enzyme-linked immu-nosorbent assay（ELISA）in 93 patients with lung cancer and 100 healthy subjects.Results The plasma TAP con-centration[（187.71 ± 82.295）μm2]in lung cancer group was significantly higher than that in the healthy control group[（67.836 ± 28.642）μm2,t=13.991,P〈0.05）.The sensitivity of TAP in lung cancer group was 83.87%. Conclusions TAP can improve the early diagnosis rate of lung cancer patients,which is important for early diag-nosis and early treatment. TAP detection is suitable for lung cancer screening in healthy people and people with high risks.