脑心通胶囊在慢性脑供血不足患者中的治疗价值探讨

Therapeutic Value of Naoxintong Capsule in Patients With Chronic Cerebral Insufficiency

目的探讨脑心通胶囊在慢性脑供血不足患者中的临床价值。方法选择2016年11月—2017年5月本院收治的慢性脑供血不足患者80例作为研究对象。将其随机分为两组,每组各40例。对照组每周进行2次双侧星状神经节阻滞,且连续治疗1个月为1个疗程,观察组在对照组基础上,联合使用脑心通胶囊(国药准字Z20025001,陕西步长制药有限公司)口服,每日3次,每次3粒,连续服用1个月为1个疗程,比较治疗后两组颅内压及脑灌注情况,及干预后1天两组ESS和MMSE评分。结果治疗后,观察组患者的脑氧分压高于对照组,差异具有统计学意义(P<0.05),脑灌注压高于对照组,差异具有统计学意义(P<0.05);干预后1天,观察组ESS和MMSE评分均高于对照组,差异具有统计学意义(P<0.05)。结论脑心通胶囊能有效改善慢性脑供血不足患者脑供血情况,提高神经功能。

Objective To investigate the clinical value of Naoxintong capsule in patients with chronic cerebral insufficiency. Methods 80 cases of patients with chronic cerebral insufficiency admitted in our hospital from November 2016 to May 2017 were selected as the study objects and they were randomly divided into two groups, 40 cases in each group. The control group was treated with bilateral stellate ganglion block twice a week. Continuous treatment one month for a course of treatment, the observation group, based on the control group, was given oral use of Naoxintong capsule（‘Chinese Medicine＇Z20025001, Shanxi Buchang Pharmaceutical Co., Ltd.）, 3 times once day, 3 particle in each day, taking one month for a course of treatment, intracranial pressure and cerebral perfusion were compared between the two groups and the ESS and MMSE scores of the two groups after 1 day of intervention. Results After treatment, the cerebral oxygen partial pressure of the observation group was significantly higher than that of the control group, the difference was statistically significant（P〈0.05）. The cerebral perfusion pressure was significantly higher than that of the control group, the difference was statistically significant（P〈0.05）.The ESS and MMSE scores of the observation group were significantly higher than those of the control group, the difference was statistically significant（P〈0.05）. Conclusion Naoxintong capsule can effectively improve the cerebral blood supply in patients with chronic cerebral insufficiency and improve neurological function.