尼莫地平联合法舒地尔治疗颅内动脉瘤介入栓塞术后脑血管痉挛的应用

Fasudil of Nimodipine in the Treatment of Cerebral Vasospasm after Intracranial Aneurysm Intervene Embolization

研究分析颅内动脉瘤介入栓塞术后应用尼莫地平联合法舒地尔对脑血管痉挛(CVS)。选择2013年1月~2016年12月收治的颅内动脉瘤介入栓塞术后脑血管痉挛的患者158例,均采用神经介入术治疗,按照用药分为观察组79例(采用尼莫地平联合法舒地尔治疗)、对照组79例(采用尼莫地平治疗)。观察两组患者术后格拉斯哥评分(COS)、大脑中、后动脉血流速度情况、不良反应等情况。结果,观察组COS评分由(8.26±1.28)分增加至(13.51±1.21)分,对照组(8.42±1.09)分增加至(10.49±1.06)分,组间比较P<0.05。观察组大脑中、后动脉血流速度治疗前分别为(101.91±32.42)cm/s、(50.72±20.65)cm/s;对照组分别为(100.12±33.61)cm/s、(50.40±20.54)cm/s;以上指标组间比较P>0.05。治疗后,观察组分别为(83.25±15.84)cm/s、(39.59±11.12)cm/s;对照组分别为(90.83±17.58)cm/s、(46.37±13.52)cm/s;P<0.05。观察组、对照组均无严重不良反应,总发生率分别为10.13%、8.86%,组间比较P>0.05。观察组总有效77例(97.45%),无效2例(2.53%);对照组总有效70例(88.61%),无效9例(11.39%),P<0.05。颅内动脉瘤介入栓塞术后应用尼莫地平联合法舒地尔对脑血管痉挛治疗效果较佳,能够促进患者神经功能的恢复,减轻COS程度,并发症少,适合临床推广。

Application study of intracranial aneurysms Interventional embolization of Nimodipine combined with fasudil on cerebral vasospasm( CVS) effect,which provided a basis for clinical application. From January 2013 to December 2016 Hospital of Neurology Interventional embolization treatment of intracranial aneurysms in patients with cerebral Vasospasm in 158 cases,neural intervention therapy,according to the drugs divided into 79 cases( using fasudil Nimodipine combined treatment),79 cases in the control group( Nimodipine treatment). All patients were observed of Glasgow Outcome Scale( COS),and artery blood flow velocity in the brain,adverse reactions. Observation of postoperative neurological deficit score by( 8.26±1.28) to increase( 13.51±1.21),postoperative neurological score of control group( 8.42±1.09) to increase( 10.49±1.06),between P<0.05. Observation groups in the brain,blood flow velocity after respectively before treatment( 101.91±32.42) cm/s,( 50.72±20.65) cm/s.The control group was( 100.12±33.61) cm/s,( 50.40±20.54) cm/s; the above indicators between the groups P>0.05.( 90.53±17.58) cm/s,(46.37±13.52) cm/s,respectively( P< 0.05),and the control group was(83.25± 15.84) cm/s and(39.59± 11.12) cm/s respectively. There were no serious adverse reactions in the observation group and the control group. The total incidence rates were10.13% and 8. 86% respectively. The difference between the two groups was P > 0. 05. There were 77 cases( 97. 45%) in the observation group and 2 cases( 2.53%). The control group was effective in 70 cases( 88.61%) and 9 cases( 11.39%),P<0.05.After Interventional embolization of intracranial aneurysms with Nimodipine combined effect of fasudil on cerebral Vasospasm treated better,and to promote the recovery of neural function of patients with,reducing the level of COS,fewer complications,and for clinical practice.