哈萨克族超体质量、肥胖学龄儿童内毒素变化及其与体格测量指标间关系

Change of plasma lipopolysaccharide in Kazakh children with overweight and obesity and its relationship with physical measurement indexes

目的了解新疆哈萨克族学龄儿童超体质量、肥胖学龄儿童内毒素(LPS)变化情况,初步探索LPS与体格测量指标间的相关性。方法从参加"新疆学龄儿童超体质量肥胖流行病学调查"的阿勒泰地区世居学龄儿童(共7 648名)中选择104名为研究对象,测量体质量、身高、腰围、臀围、血压各项体格指标,计算体质量指数(BMI)、腰围身高比(WHtR),并检测LPS及血糖血脂等生化指标。结果随着BMI的增高,腰围、臀围、收缩压(SBP)、WHtR均增高;肥胖组的LPS、三酰甘油(TG)均明显高于超体质量组及对照组;LPS分别与BMI分级(正常、超体质量、肥胖3个等级)、腰围、WHtR呈现正相关(r=0.865、0.556、-0.477,P=0.000);WHtR异常增高的哈萨克族学龄儿童具有更高的血压及LPS水平;WHtR与SBP存在正相关(r=0.441,P=0.000)。结论 LPS与哈萨克族学龄儿童超体质量、肥胖相关,腹型肥胖的哈萨克族学龄儿童更易出现SBP异常增高及LPS水平增高情况。

Objective To understand the change of plasma lipopolysaccharide（LPS）in Kazakh children with overweight and obesity and to investigate the correlation between LPS and physical measurement indexes.Methods One hundred and four children were selected from 7648 native school age children in Altay area participating in the Epidemiological Investigation of Overweight and Obesity of School Age Children in Xinjiang as the research subjects.The physical measurement indexes such as body weight,height,waist circumference（WC）,hip circumference（HP）and blood pressure were measured,and the body mass index（BMI）and waist to height ratio（WHtR）were calculated.LPS and biochemical indexes such as blood glucose（FPG）and blood lipid were detected.Results With BMI increase,the indexes including WC,HP,systolic blood pressure（SBP）and WHtR were also increased.The serum LPS and TG levels in the obesity group were significantly higher than those in the overweight group and control group.LPS had positive correlation with BMI grade（normal,overweight and obesity）,r=0.865,P=0.000,and also had positive correlation with WC（r=0.556,P=0.000）and WHtR（r=0.477,P=0.000）respectively;the Kazakh school age chidren with WHtR abnormal increase had higher blood pressure and LPS level.WHtR and SBP had a positive correlation（r=0.441,P=0.000）.Conclusion LPS is correlated with overweight and obesity in Kazakh school age children.The child with abdominal obesity is easier to appear SBP abnormal elevation and LPS level increase.