ACEI/D基因多态性与偏头痛易感性的Meta分析

Meta analysis on ACE I/D gene polymorphism and migraine

目的探讨血管紧张素转换酶基因(ACE)I/D位点基因多态性与偏头痛易感性之间的关系。方法通过检索PubMed和EMBASE数据库收集已发表的有关ACE I/D基因多态性与偏头痛易感性关系的病例对照研究,通过固定效应模型或随机效应模型合并效应量OR和95%CI以评价ACE I/D多态性与偏头痛易感性的关联性,同时进行种族及偏头痛类型亚组分析。结果 Meta分析中纯合子模型(DDvs.II:OR=1.21,95%CI:1.02~1.44,P=0.03;I2=47%)和显性模型(DD+DI vs.II:OR=1.16,95%CI:1.01~1.33,P=0.04;I2=50%)均提示ACE I/D多态性与所有偏头痛的易感性呈正相关。杂合子模型和显性模型提示ACE I/D多态性显著增加有先兆偏头痛的易感性。结论 ACE基因I/D位点多态性与偏头痛易感性相关,其D等位基因是偏头痛的危险因素,特别是显著增加有先兆偏头痛的易感性。

Objective To investigate the association between the angiotensin-converting enzyme（ACE）I/D locus polymorphism and migraine susceptibility.Methods The case control studies on the relation between ACE I/D gene polymorphism and migraine susceptibility published in the databases of PubMed and EMBAE were retrieved.The relationship between ACE 1/D polymorphism and migraine was evaluated through the effect size（OR）and 95% confidence interval（CI）by fixed-effects model or random-effect models.Meanwhile the subgroup analysis of ethnicity and migraine types was performed.Results In meta analysis,the homozygote model（DDvs.II：OR=1.21,95%CI：1.02-1.44,P=0.03;I2=47%）and dominant model all indicated that the ACE I/D polymorphism was positively correlated with the susceptibility of all migraine.The heterozygote model（DI vs.II：OR=1.35,95%CI：1.06-1.72,P=0.02;I2=10%）and dominant model（DD＋DI vs.II：OR=1.37,95%CI：1.09-1.73,P=0.00;I2=40%）indicated that ACE I/D polymorphism significantly increased the susceptibility of migraine with aura.Conclusion The ACE I/D locus polymorphism is correlated with migraine susceptibility,its D allele is a risk factor of migraine,which especially increases the susceptibility of migraine with aura.