单核细胞趋化蛋白-1-2518G/A位点基因多态性与糖尿病肾病易感性的Meta分析

Meta analysis on MCP-1-2518G/A gene polymorphism and susceptibility of diabetic nephropathy

目的评估单核细胞趋化蛋白-1(MCP-1)-2518G/A基因多态性与糖尿病肾病(DN)发病风险的关系。方法系统检索PubMed、Web of Science、EMbase、Cochrane Library、中国知网(CNKI)、万方和维普数据库中截至2016年10月收录的所有有关MCP-1-2518G/A基因多态性与DN发病风险的文献。提取相关数据,应用STATA11.0统计软件计算合成数据的比值比(OR)和95%可信区间(CI),同时评估研究的异质性、发表偏倚。结果共纳入的9项研究涉及2 767例独立样本,其中病例组为1 096例,对照组为1 671例。对于总体人群,在4个基因模型中均未发现MCP-1-2518G/A多态性与DN发病风险有关(显性模型:OR=1.01,95%CI:0.67~1.54;隐性模型:OR=0.93,95%CI:0.60~1.44;纯合子模型:OR=0.93,95%CI:0.70~1.23;杂合子模型:OR=0.89,95%CI:0.61~1.31)。亚组分析结果显示,在印度人群中,MCP-1-2518G/A基因多态性会显著增加DN的发病风险(显性模型:OR=1.56,95%CI:1.19~2.06),但在中国人、土耳其人及韩国人中均未发现MCP-1-2518G/A基因多态性与DN的发病风险有关。结论总体人群中,MCP-1-2518G/A位点基因多态性与DN发病风险无关,但MCP-1-2518G/A位点多态性会增加印度人群DN发病风险,而不增加中国人群、韩国人群、土耳其人群中DN的发病风险。

Objective To evaluate the relation between MCP-1-2518 G/A gene polymorphism and the onset risk of diabetic nephropathy（DN）by the data of collected and publishedcase control studies and using the meta analysis method.Methods All literatures on moncyte chemoattractant protein-1（MCP-1）-2518 G/A gene polymorphism and the onset risk of DN included in the databases of PubMed,Web of Science,EMbase,Cochrane Library,CNKI,Wanfang and VIP until October 2016 were systametically retrieved.Then the related data were extracted.The Stata11.0 statistical software was used to calculate the odds ratio（OR）of synthetic data and 95% confidence interval（CI）,meanwhile the heterogeneity and publication bias of the studies were evaluated.Results A total of 9 studies were included involving 2767 independent samples,the number of cases was 1096,the control number was1671.For the general population,the relationship between MCP-1 gene-2518 G/A polymorphism and the onset risk of DN was not found in 4 gene models（dominant model：OR=1.01,95%CI：0.67-1.54;recessive model：OR=0.93,95%CI：0.60-1.44;homozygous model：OR=0.93,95%CI：0.70-1.23;heterozygous model：OR=0.89,95%CI：0.61-1.31）.The subgroup analysis results showed that in India population,MCP-1-2518 G/A gene polymorphism might significantly increase the onset risk of DN（dominant model：OR=1.56,95%CI：1.19-2.06）,but in Chinese,Turks or South Koreans,the MCP-1-2518 G/A gene polymorphism had no relation with the onset risk of DN.Conclusion In the general population,MCP-1-2518 G/A gene polymorphism has no relation with the onset risk of DN.But the MCP-1 gene-2518 G/A polymorphism can increase the onset risk of DN in India population,while does not increase the onset risk of DN in Chinese population,Korean population and Turkey population.