探讨分析生长抑素、凝血酶联合奥美拉唑治疗上消化道溃疡出血患者的临床效果及安全性

Investigation and analysis on clinical effect and safety of somatostatin and thrombin combined with omeprazole in patients with upper gastrointestinal ulcer bleeding

目的分析生长抑素、凝血酶联合奥美拉唑治疗上消化道溃疡出血的临床效果及安全性。方法 88例上消化道溃疡出血患者,采取随机抽签的方式分为观察组和对照组,各44例。对照组仅给予奥美拉唑治疗,观察组给予生长抑素+凝血酶+奥美拉唑联合治疗,比较两组患者的临床效果、出血量、止血时间、住院时间及不良反应发生情况。结果观察组总有效率显著高于对照组,差异有统计学意义(P<0.05)。观察组患者出血量为(395.55±80.12)ml,止血时间为(7.01±2.19)h,住院时间为(10.27±2.44)d,均分别优于对照组的(513.74±89.63)ml、(9.58±3.04)h、(12.88±3.28)d,差异有统计学意义(P<0.05)。观察组不良反应发生率为6.8%(3/44),对照组不良反应发生率为9.1%(4/44),两组比较差异无统计学意义(P>0.05)。结论生长抑素、凝血酶联合奥美拉唑治疗上消化道溃疡出血具有显著疗效,且不良反应少,安全性高,适宜在临床上推广。

Objective To analyze the clinical effect and safety of somatostatin and thrombin combined with omeprazole in patients with upper gastrointestinal ulcer bleeding.Methods A total of 88 patients with upper gastrointestinal ulcer bleeding were divided by random lottery method into observation group and control group,with 44 cases in each group.The control group was treated with omeprazole,and the observation group was treated with somatostatin ＋ thrombin ＋ omeprazole.Comparison were made on clinical effect,bleeding volume,hemostatic time,hospitalization time and adverse reactions between two groups.Results The observation group had obviously higher total effective rate than the control group,and the difference was statistically significant（P0.05）.The observation group had bleeding volume as（395.55±80.12） ml,hemostatic time as（7.01±2.19） h,hospitalization time as（10.27±2.44） d,which were all better than（513.74±89.63） ml,（9.58±3.04） h,（12.88±3.28） d in the control group,and their difference was statistically significant（P0.05）.The observation group had incidence of adverse reactions as 6.8%（3/44）,while the control group had incidence of adverse reactions as 9.1%（4/44）,and their difference was not statistically significant（P0.05）.Conclusion Somatostatin and thrombin combined with omeprazole shows excellent efficacy in treating upper gastrointestinal ulcer bleeding with less adverse reactions and high safety.It is suitable to be popularized in clinic.