天香丹颗粒对冠心病心绞痛(痰瘀互阻型)患者的影响

Impact of Tianxiangdan Granules on Coronary Heart Disease and Angina Pectoris Patients Performed as TCM Syndrome of Phlegm Stasis

目的探讨天香丹颗粒对冠心病心绞痛(痰瘀互阻型)患者的影响。方法选取2015年6月—2016年7月新疆医科大学附属中医医院收治的冠心病心绞痛(痰瘀互阻型)患者70例,采用随机数字表法分为对照组和观察组,每组35例。在常规治疗基础上,对照组患者给予心可舒片治疗,观察组患者在对照组基础上给予天香丹颗粒治疗。比较两组患者治疗前后中医症状评分、炎性因子[肿瘤坏死因子α(TNF-α)、白介素6(IL-6)、干扰素γ(INF-γ)]及心电图改善效果。结果治疗前两组患者胸闷评分、胸隐痛时作评分、脉虚评分、脉滑评分、气促乏力评分、肢体沉重评分、舌质暗或瘀斑评分比较,差异无统计学意义(P>0.05);治疗后观察组患者胸闷评分、胸隐痛时作评分、脉虚评分、脉滑评分、气促乏力评分、肢体沉重评分、舌质暗或瘀斑评分低于对照组(P>0.05)。治疗前两组患者血清TNF-α、IL-6、INF-γ水平比较,差异无统计学意义(P>0.05);治疗后观察组患者血清TNF-α、IL-6、INF-γ水平低于对照组(P<0.05)。观察组患者心电图改善效果优于对照组(P<0.05)。结论天香丹颗粒能有效减轻冠心病心绞痛(痰瘀互阻型)患者中医症状及炎性反应,改善患者心功能。

Objective To investigate the impact of Tianxiangdan granules on coronary heart disease and angina pectoris patients performed as TCM syndrome of phlegm stasis. Methods A total of 70 coronary heart disease and angina pectoris patients performed as TCM syndrome of phlegm stasis were selected in TCM Hospital Affiliated to Xinjiang Medical University from June 2015 to July 2016,and they were divided into control group and observation group according to random number table,each of 35 cases. Based on conventional treatment, patients of control group received xinkeshu tablets, while patients of observation group received Tianxiangdan granules based on that of control group; both groups continuously treated for 4 weeks. TCM symptoms score,serum levels of TNF-α,IL-6 and INF-γ before and after treatment,and ECG improvement were compared between the two groups. Results No statistically significant differences of chest distress score,unmeant chest dull pain score,feeble pulse score,slippery pulse score,anhelation and lacking in strength score,limbs heaviness score,dull-red or ecchymotic tongue body score was found between the two groups before treatment（ P〉0. 05）,while chest distress score,unmeant chest dull pain score, feeble pulse score, slippery pulse score, anhelation and lacking in strength score, limbs heaviness score,dull-red or ecchymotic tongue body score in observation group were statistically significantly lower than those in control group after treatment（ P〉0. 05）. No statistically significant difference of serum level of TNF-α,IL-6 or INF-γ was found between the two groups before treatment（ P〉0. 05）,while serum levels of TNF-α,IL-6 and INF-γ in observation group were statistically significantly lower than those in control group after treatment（ P〈0. 05）. ECG improvement rate in observation group was statistically significantly higher than that in control group（ P〈0. 05）. Conclusion Tianxiangdan granules can effectively relieve the TCM symptoms and inflammatory reaction, improve the cardiac function in coronary heart disease and angina pectoris patients performed as TCM syndrome of phlegm stasis.