PET/CT SUV_(max)值对体部伽玛刀治疗胰腺癌患者预后的评估价值分析

Prognostic value of PET/CT SUV_(max) in patients with pancreatic cancer treated by body gamma knife

目的分析体部伽玛刀治疗胰腺癌患者的临床疗效及PET/CT SUV_(max)值与放疗预后的相关性。方法选取接受伽玛刀治疗的54例胰腺癌病例为研究对象,所有患者于放疗2周前进行18F-FDG PET/CT检查,计算SUVmax值,分析其对患者预后的影响及患者的放射反应情况。结果 54例患者放疗后疼痛完全缓解13例(24.1%),部分缓解28例(51.9%),轻微缓解6例(11.1%),总有效率为87.0%;体部伽玛刀治疗胰腺癌患者的临床疗效及PET/CT SUV_(max)值与放疗预后有关。患者在放疗期间出现的不良反应主要是血液学的不良反应和急性消化道反应,未出现3级及以上的急性、晚期放射反应,治疗结束后患者症状逐渐消失。结论体部伽玛刀治疗胰腺癌止痛效果明显,近期疗效好,不良反应小,并发症可以接受。胰腺癌患者伽玛刀放疗预后可用PET/CT SUV_(max)值预测。

Objective Analysis of the clinical efficacy of body gamma knife in the treatment of pancreatic cancer and the correlation between the PET/CT SUVmaxvalue and the prognosis of radiotherapy. Method 54 cases of pancreatic cancer patients who received gamma knife treatment were enrolled in the study. All patients received18 F-FDG PET/CT examination 2 weeks before radiotherapy. The SUVmaxvalue was calculated, the prognosis and the reflex reaction of these patients were analyzed. Result Of the 54 patients, 13 cases（24.1%） achieved complete pain relief after radiotherapy, 28 cases（51.9%） had partial remission, 6 cases（11.1%） had mild remission, and the overall response rate was 87.0%. The clinical efficacy and PET/CT SUVmaxvalue of patients with pancreatic cancer treated by body gamma knife were related to the prognosis of radiotherapy. The main side effects of radiation therapy were hematological adverse reactions and acute gastrointestinal reactions. No acute or late stage radiation reactions of grade 3 or more occurred. Symptoms disappeared after treatment was completed. Conclusion The effect of the body gamma knife in the treatment of pancreatic cancer is obvious, with fair short-term efficacy, and minor adverse reactions, besides, the complications are tolerated. The prognosis of gamma knife radiotherapy in patients with pancreatic cancer can be predicted by PET/CT SUVmaxvalue.