分子印迹聚合物在中药活性成分分离中的应用进展

Application progress of molecularly imprinted polymers in separation of active ingredients from Chinese materia medica

分子印迹聚合物分离中药活性成分具有快速、成本低廉、可重复使用以及环境污染小等优势,其合成以及应用于分离研究越来越受到世界中药化学家们的青睐,而探索印迹聚合物的结构与中药活性成分离效率之间规律关系是该研究领域的核心内容。基于中药活性成分的种类(黄酮、生物碱、苯丙素、萜类等)分类阐述各分子印迹聚合物的设计原理、制备方法以及在中药活性成分分离纯化中的最新应用,以期为后续设计选择性更高的中药活性成分分离新材料提供参考。

Separation of active ingredients from Chinese materia medica（CMM） by molecularly imprinted polymers has such advantages as high speed,low cost,being reusable,low pollution,and so on.Because of this reason,the synthesis of molecularly imprinted polymers and its application in separation have drawn more and more attention of researchers in the field of CMM all over the world.Obviously,the core of this research is to explore the relationship between the polymer-structure and separation efficiency.Based on the types of active ingredients of CMM（flavone,alkaloids,phenylpropanoids,terpenoids,etc.）,the design principle of molecularly imprinted polymer,its preparation methods and latest application in separation of active ingredients from CMM were introduced.Therefore,this paper can provide a reference for designing new materials with higher selectivity in separation of active ingredients from CMM.