摘要
转录因子E3（TFE3）位于X染色体11.2,在细胞的生长、分化、转录调控等方面发挥重要作用.病理情况下TFE3基因发生易位形成融合基因,使TFE3蛋白异常高表达,影响细胞转录调控,促进肿瘤形成.文章就几种TFE3融合基因相关肿瘤的临床病理特征进行综述,以提高对该类疾病的认识.
Transcription factor E3 （TFE3） located in the X chromosome 11.2 plays an important role in cell growth, differentiation and transcription regulation. In the condition of pathology, the TFE3 gene translocates to form fusion genes, which makes the expression of TFE3 protein abnormally high, and affects the transcriptional regulation of cells and promotes the tumor formation. This article reviews the clinicopathological features of several TFE3 fusion genes related tumors,in order to improve the recognition of this disease.
出处
《肿瘤研究与临床》
CAS
2017年第12期854-857,共4页
Cancer Research and Clinic
