不同剂量及疗程的氨甲环酸治疗黄褐斑疗效比较

Comparison of Therapeutic Effects of Different Doses and Courseswithtranexamic Acid in 72 Cases of Chloasma

目的:比较口服不同剂量及疗程的氨甲环酸治疗黄褐斑的临床疗效及不良反应。方法:将72例患者随机分为三组,治疗A组:25例,口服氨甲环酸0.25g/d,6个月;治疗B组:28例,口服氨甲环酸1.0g/d,3个月;对照组:19例,口服维生素C 0.6g/d,3个月。各组患者均外用3%熊果苷3个月。分别于治疗结束时及治疗结束后6个月由医师观察疗效及不良反应,由患者进行满意度评估。结果:治疗结束时及治疗结束后6个月,两治疗组疗效均优于对照组;治疗结束后6个月,治疗A组优于治疗B组。两治疗组均无明显不良反应。结论:低剂量、长疗程口服氨甲环酸治疗黄褐斑更安全、有效。

Objective To observe the clinical effects and adverse reactions of oral administration of tranexamic acid in treating chloasma with different doses and courses.Methods Seventy-two cases of chloasma were randomly divided into three groups,group A,group B and group C.Cases in group A（n=25）were treated with tranexamic acid of 0.25g/d combination with topical 3%arbutin for three months,while 28 cases in group B were treated with tranexamic acid of 1.0g/d as well as 3%arbutin for three months.Besides,19 cases were brought into group C as the control group and treated with vitaminC 0.6g/d combination with topical 3%arbutin for three months.Effects and adverse reactions were observed by dermatologistat the end of treatment and 6 months after the treatment.Results The effects in treatment groups were superior to those in the control group.Further,there was better efficacy of group A than group B at 6 months after the treatment.No adverse reactions were found in treatment groups.Conclusion Low-dose and long-term therapy with tranexamic acid administered orally to treat chloasma is effective and safe.