摘要
以2,4,5-三甲氧基苯甲酸和2-氨基噻唑-4-甲酸乙酯为起始原料,经缩合、脱甲基、胺解和成盐等反应得到盐酸阿考替胺。制备工艺安全,反应步骤少,操作简单,适合工业化。
2,4,5-trimethoxybenzoic acid and 2-amino thiazole-4-ethyl formate make Acotiamide Hydrochloride by ondensation、demethylation、amination and salt-forming reaction The preparation process is safe,with less reaction steps and simple operation,which is suitable for industrialization.
出处
《山东化工》
CAS
2017年第24期41-41,44,共2页
Shandong Chemical Industry
关键词
盐酸阿替考胺
消化不良
合成
acotiamide hydrochloride
indigestion
synthesis
