支原体感染与生殖系统肿瘤关联性研究的系统评价

Association of mycoplasma infection with genital system tumor:A system evaluation

目的探讨支原体感染与生殖系统肿瘤的关联性。方法以支原体与生殖系统肿瘤(包括前列腺癌、宫颈癌、卵巢癌)为检索词,在PubMed、Web of Science、中国生物医学文献数据库、万方数据库、中国知网等系统检索,收集公开发表的有关支原体与生殖系统肿瘤的研究文献。使用R软件进行Meta分析,用NOS质量评价量表对文献进行质量评估。采用拉贝图检验纳入文献的一致性,计算失安全系数,评价合并结果的稳定性。结果共纳入20篇文献,累计病例2 345例,对照2 728例。计算不同支原体与生殖系统肿瘤关系的合并OR值,其中Uu合并OR=2.19(95%CI:1.27~3.79);Mh合并OR=1.74(95%CI:1.28~2.35);其他支原体合并OR=1.97(95%CI:1.03~3.77);混合支原体合并OR=3.54(95%CI:1.33~9.41);总体合并OR=1.29(95%CI:1.53~2.60)。各组的失安全系数分别为Nfs(Uu)=254,Nfs(Mh)=42,Nfs(other)=31,Nfs(混合)=157。结论支原体感染与生殖系统肿瘤具有一定的关联性,可能增加其发生的危险性,有必要进一步研究不同类别的支原体感染与肿瘤的关系。

We explore the association of the mycoplasma infection with genital system tumor.Some index word including prostate cancer,cervical cancer,ovarian cancer and mycoplasma were used in some electronic databases(including PubMed,Web of Science,Chinese biomedical database,wanfang database,CNKI)to search literatures.The R software was used for the meta-analysis.The Newcastle-Ottawa Scale(NOS)was used to evaluate the quality of the literature.Publication bias was evaluated by funnel figure,and the fail-safe number(Nfs)was calculated to estimate the reliability of the meta-analysis.Result showed that 20 articles were included,the numbers of cases and controls were 2 345 and 2 728 respectively.The pooled OR of Ureaplasma urealyticum(Uu),Mycoplasma hominis(Mh),other mycoplasma,mixture of mycoplasma and the whole mycoplasma was 2.19(95%CI:1.27-3.79),1.74(95%CI:1.28-2.35),1.97(95%CI:1.03-3.77),3.54(95%CI:1.33-9.41),1.29(95%CI:1.53-2.60),respectively.The fail-safe number of Uu,Mh,other mycoplasma and mixture of mycoplasma was 254,42,31,157 respectively.There are some possibility about the association between the mycoplasma infection and the genital system cancer;maybe the infection would increase the tumorigenesis risk.It is necessary to research further about these associations in different mycoplasmas respectively.